The Evolutionary Theories of Aging Revisited – A Mini-Review
نویسندگان
چکیده
منابع مشابه
The evolutionary theories of aging revisited--a mini-review.
This short review portrays the evolutionary theories of aging in the light of the existing discoveries from genomic and molecular genetic studies on aging and longevity. At the outset, an historical background for the development of the evolutionary theories of aging is presented through the works of August Weismann (programmed death and the germ plasm theories) including his exceptional theore...
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This article reviews some studies testing evolutionary theories of aging and shows that they are not always confirmed. Nevertheless, many gerontologists consider now that these theories provide a general explanation of the aging process. In such conditions, we may wonder whether time has come to provisionally accept these theories in order to redirect the research efforts of gerontologists towa...
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Several factors have incentive role for study of aging which includes increasing of the average and maximum of human life span, the increase in percentage of elderly in the societies and proportion of the national expenditure utilized by them. The Recent views of aging indicating that aging is extremely a complex multifactorial process despite of earlier views about definite cause aging like ge...
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Senescence is a nearly universal feature of multicellular organisms, and understanding why it occurs is a long-standing problem in biology. The two leading theories posit that aging is due to (i) pleiotropic genes with beneficial early-life effects but deleterious late-life effects ("antagonistic pleiotropy") or (ii) mutations with purely deleterious late-life effects ("mutation accumulation")....
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high‐throughput chemical genetic screen of chemical compounds from several commercial libraries has revealed that lithocholic bile acid (LCA), and some other bile acids, can slow yeast chronological aging [1]. The robust geroprotective effect of exogenously added LCA is due to its ability to enter chronologically aging yeast cells, be sorted to both mitochondrial membranes and alter mitochondri...
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ژورنال
عنوان ژورنال: Gerontology
سال: 2009
ISSN: 0304-324X,1423-0003
DOI: 10.1159/000200772